![]() So, off we went, driving the freeway past some of the skyscrapers that make up part of Miami's iconic skyline, across a large bridge to a big island on which sits Miami Beach and many, many cruise ships. Let me get the address for you." After providing the address and calling to find out when it opened, she said we should try their creamed spinach, coleslaw, hash browns and Key lime pie. The legendary eatery in Miami Beach makes a delicious classic. I recalled reading about the restaurant and asked a clerk in the gift shop about a famous place in Miami that sells stone crabs. Joes Stone Crab perfects the art of the Key Lime Pie just as well as its stone crabs. We went there and afterwards decided we wanted to find a place to eat. The number one activity, according to Trip Advisor, is Vizcaya Museum & Gardens. Go to the Keys if you want good key lime pie is the most common answer for those who crave this sweet-and-tart dessert. She notes that the claws are served in four sizes, are served with "mustard sauce or melted butter, hash browns or cottage-fried sweet potatoes, coleslaw and creamed spinach." Oh, and, "Save room for dessert: Joe's Key lime pie is the real thing." I didn't put Joe's on my list of things to do, but as Judy and I were driving from Orlando to the Everglades, and noting the Miami skyline in the distance, Judy went to Trip Advisor to look for something to do in Miami. Lower the mixer speed and slowly add the juice, mixing for one more minute until combined. Gradually add the condensed milk and beat until thick, 3 to 4 minutes. ![]() In a bowl, beat the egg yolks and the lime zest for 5 minutes, with an electric mixer at high speed, until the mix is fluffy. Keep it cool this summer with Joe’s Seafood, Prime Steak & Stone Crab’s renowned Key Lime Pie.This iconic dessert’s creamy frozen filling, made with a combination of sweetened condensed milk, zesty lime juice, and a touch of lime zest, delivers a tangy and refreshing burst of flavor that will transport your taste buds to. Eleven out of the 1,000 places are in Florida and include such well known destinations as the Kennedy Space Center, Everglades National Park, Daytona Speedway, Walt Disney World, the Florida Keys, South Beach and, say what? - Joe's Stone Crab in Miami Beach? Are you kidding me? What is a restaurant doing on this list? Schultz calls Joe's a "South Beach Institution" and "possibly the nation's number one crab institution." She says that the stone crab is found only in southwestern Florida, the Keys and along the Gulf of Mexico. 2/3 cup of fresh limes (lemons) Preheat the oven to 350☏. Recipe by Joe’s Seafood, Prime Steak & Stone Crab. For our visit to Florida we consulted 1,000 Places to See Before You Die by Patricia Schultz to get an idea of places we ought to see while there.
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![]() By summer 2002, they'd recorded an EP's worth of material that they intended to release themselves, but word of mouth about the band spread and Franz Ferdinand signed to Domino in the summer of 2003. ![]() The bandmembers needed a new rehearsal space once their illicit art parties were discovered by the police, and they found one in a Victorian courthouse and jail. The Chateau became Franz Ferdinand's headquarters, where they rehearsed and held rave-like events incorporating music and art (Hardy graduated from the Glasgow School of Art, and Thomson also posed as a life model there). Eventually, McCarthy and Thomson switched to guitar and drums, and the band switched practice spaces, moving to an abandoned warehouse that they named the Chateau. The trio had rehearsed at McCarthy's house for a while when they met and started playing with Paul Thomson, a former drummer for the Yummy Fur who felt like playing guitar instead. ![]() In late 2001, singer/guitarist Alex Kapranos and bassist Bob Hardy began working on music together when they met Nick McCarthy, a classically trained pianist and double bass player who originally played drums for the group despite no prior experience as a drummer. I hope you enjoy the rest of it.Named for the Austro-Hungarian Archduke whose murder sparked World War I, Glasgow's Franz Ferdinand helped define the sound of the 2000s and 2010s with their mix of arty rock, dance music, dub, and more. Don’t worry: I promise this is as lengthy as my posts will ever get. There’s a lot of reasons and I’m hoping, at the end of this week, that I can just rattle off the OWOB url and leave it at that. Most of the time, I’m stumbling over myself trying to concisely sum up what it is about the Glaswegian four-piece that makes them my one band. It leads to a certain qualification that I feel pressed to give once the band name comes up. “Franz Ferdinand? Really? Are they even still around? I mean their first album was good, but…” I’ve seen and heard it all, but usually that’s the gist of their response. Telling people (especially people who work in music) that I’m partial to them tends to yield raised eyebrows and fleeting glances of concern. I’m aware this is a lofty statement given the number of bands that have and continue to exist – but for me, it’s been Franz Ferdinand for a long time. ![]() This week has given me the excuse to reacquaint myself with Franz Ferdinand’s rather extensive back catalogue and it’s been a big reminder of why they’re my absolute favourite band in the history of any band to ever band. There will be a couple of deviations, but for the most part we’re going from the 2002 beginnings to the present.) (I’ll also note that I’m mostly going to run this chronologically because otherwise my linear brain can’t really make sense of it. There’s obviously more to Franz Ferdinand and their records that extends beyond my super simple summation of “pop music = good”, but that’s where we’ll start. It’s all played a role in legitimizing pop music, but I like to think Franz Ferdinand had something to do with it, too. Yes, interest and appreciation for pop has inevitably changed over the years as things like the Internet (hi!), song streaming, and diverse festival lineups have come in. They were the bridge between massive, catchy hooks and the idea that: “That band has guitars, they must know what they’re doing.” You didn’t really have to think about what they were doing to be able to respond to it, and that was and still is this music’s strength. I say this because Franz Ferdinand, for me, came about as the band that made pop music for people who weren’t sure that liking pop music was okay. With my time on OWOB, I get to try and use all of the words I’ve ever learned to sum up the still-ongoing career of Franz Ferdinand and contextualize it in the great sweeping theme of: It’s okay to like pop music. I’m lucky to do it.īut back to this, and my hope that at least a small fraction of you will enjoy the upcoming week. It’s equal parts exhausting and the best thing in the world. Occasionally people let me take photos and write things about said shows. I work in marketing and music by day and I go to as many shows as possible by night. My name is Sarah Rix and I’m from the fantastic city of Toronto. I think this is the part where I say hello to everyone on the Internet. Thank you for the introduction, Hendrik, and thank you for the opportunity to contribute to the wonderful One Week // One Band. ![]() The following functionality is not supported for Fujifilm X-trans RAW files: processing/exporting to DNG. When you have disconnected a camera, do not reconnect a camera until the Camera tool status changes to "No Camera Attached".ĭNG support not optimized for some cameras. You can also schedule an automated update if needed by navigating to Capture One -> Preferences (Edit -> Preferences on Windows). If your Capture One application is downloaded from it will always be the latest version. After the activation and registration, you will usually receive a newsletter reminder that an update is ready for download, although it can be more convenient to choose Capture One -> Check for Updates (Help -> Check for Updates on Windows). It is important to keep Capture One software updated. Open Capture One from your Applications folder. NET Framework 4.7 if you do not already have it.ĭrag the Capture One icon to the Applications folder. Capture One will initiate the installation of Microsoft®. Run the executable software install file (.exe).Ĭarefully read and accept the license agreement presented.įollow the on-screen instructions to complete the installation. To install the software please follow the procedure below.ĭownload the application from the Capture One website. Please read the release notes carefully before you install Capture One. ![]() Multi-user licenses are also available from the Capture One web shop or from your retailer. The license can be used with both Windows and Mac platforms. A single-user license allows up to 3 activations on computers that you own or of which you are the principal user. It is generally recommended that you only install one version of Capture One on any single computer. It is recommended to migrate images from 4.x, 5.x., and 6.x to version 8.x before opening them in the latest version of the app. The latest version of Capture One is compatible with the earlier 7.x, 8.x, 9.x, 10.x, 11.x, 12.x versions. *MacOS is supported for versions up to 11.7, 12.6 and 13.5. *Windows 10 is supported for versions from 20H2 through to 22H2. Internet connection to run Capture One Live.Calibrated monitor with 1280x800, 24-bit resolution at 96dpi.Intel® Core™ i3 (1st generation) / AMD Jaguar family.We recommend that your computer has at least the minimum specifications outlined below to run Capture One. Sigma 60-600 F4.5-6.3 DG DN OS | S (Sony E)įixed an issue where applying a preset/style with light falloff would make the image overexposedįixed an issue where copying filled parametric adjustments layer from landscape to portrait (and vice-versa) would not resizeįixed an issue where some Collections may be empty after restarting Capture One. Previous release notes can be found here.Ĭapture One 23 (16.2.4) is a service release containing multiple bug fixes, additional camera and lens support including Apple iPhone as a tethered capture device (Capture One mobile subscription required) and the brand new Fujifilm GFX100 II. ![]() The trial is also included in the installer and is registered as the full product upon activation. It offers state-of-the-art tethered capture, powerful digital asset management, extensive adjustment tools, and a flexible workflow through customizable workspaces.Īll run modes are included in one installer and the run mode is determined by the license key that is used. Capture One is a powerful RAW converter offering you ultimate image quality with beautiful colors and incredible detail. ![]() Set Y axis color to follow plot color in multi-Y plots.Isometric layer scaling to link axes length to scale by X/Y ratio (2D plots) and X/Y/Z ratio (3D plots).Copy axis format to other layer or graphs.Customize one axis at a time or multiple axes together.Multiple Axis Breaks with customization of scale and tick labels of each individual segment, and control of break gaps.Supported axis break customization includes: break styles, define gap, break region, break position along axis, scale type and increment before/after break.Customize axis title, including units for different conventions, e.g.Remove exponential notation common to all tick labels and add to end of axis.Flexible Minor Tick Label Display Format, separate from major ticks.Tick labels displayed as table, with flexible customization of table grid lines, text orientation and positioning.Wrap, rotate tick labels, position it at tick, next to tick or between two ticks.Tick labels can be from a column of values or a combination of column labels.Many tick label types from numeric, text, date, time, month, week, etc.Lines are saved in graph template for repeated use. ![]() Use custom equations or expressions to add lines based on axis scale values.Functions can be combined, such as mean+1.5*sd.Show linear fit curve, confidence band, etc.Use statistical functions on plotted data, such as mean and standard deviation.Multiple reference lines and shading between, in 2D graphs.Option to show axis and grids on top of data.Additional axis line at any position to be used as baseline for column/bar plots and drop lines.Independent control axis line, major ticks and minor ticks.Multiple Special Ticks with detailed tick and label formatting for each tick.Major and minor ticks can be set by increment, counts, from a dataset, from column label row, or at user-specified positions.Discrete scale type for skipping rows without data, therefore exclude weekends and holidays for financial data.User-defined axis scale type using formulas.Positive and negative symmetrical log scale.Support multiple scale types such as linear, log10, Probability, Reciprocal ect.Group multiple plots for easy customization.Single Point and Multiple Plots Customization Show error bar as bands with filled colors.Auto-positioning of labels to avoid overlapping.Align Left, Center or Right option for multi-line labeling. ![]()
To make this connection, you will need a junction box. How do you connect four wires to 2 wires?Ĭonnecting a four wires circuit to a two-wire line can be challenging. Then connect the black wire of the 3-wire cable to either the red or black wires of the 4-wire cable.Įnsure the twist caps and tightened and should not be easy to pull off once they are tightly secured. Place ½ inch wire inside the hole and tilt the wire stripper 45 degrees toward the wire and pull.Ĭonnect the white wire from the 3-wire cable to the white wire from the 4-wire line using plastic twist caps.Ĭonnect the ground wire from the 3-wire cable to that of the 4-wire line. For example, working with a 12 gauge wire slot is inside a 12 gauge hole. Slot the wire into a hole matching its size. Then strip ½ inch of insulation off the ROMEX wire’s black, red, and ground wires. ![]() Slot a ROMEX wire in the knockout hole you have created using a three-wire cable ROMEX wire. Knockouts are small access holes created to allow new entry points inside the junction box. Use a screwdriver and a hammer to create a knockout hole inside the junction box. This is done by switching off the breaker that powers the circuit. Start by shutting off power to the primary four-wire circuit. Here is how to connect the two-wire circuits On the other hand, the three-wire circuit will have a red, black, and ground wire configuration. The four-wire circuit will have a red, black, white, and ground wire configuration This is mainly used for large lighting applications. This is done to connect two 110v circuits to one 220v circuit. Wiring homeline qo breakerSquare d qo 30 amp load center wiring diagram Breaker installation homeline qoLoad wiring center diagram homeline amp square qo panel.You can connect a four-wire circuit to a three-wire in a junction box. Wiring diagram homeline load center100 load center wiring diagram Siemens load wiring diagram center centers phase lug single main30 amp qo breaker wiring diagram. Check Details Square d qo 30 amp load center wiring diagram Load center wiring diagramsCircuit siemens homeline 70a amps bestpick Square d load center wiring diagramSiemens w0408ml1125 single-phase main lug load centers. Wiring diagram load center square240 volt plug wiring diagram Square d load center wiring diagramHomeline 70 amp load center wiring diagram gallery. Check Details Breaker wiring volt homeline fuse 240v electrical switch cl500 mikrora Square d qo 30 amp load center wiring diagramHomeline load center wiring diagram Wiring diagram load center qo amp square 30a librar圓0a load center wiring diagram. 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Wiring qo load diagram center square amp lair nlSquare d homeline load center wiring diagram Wiring diagram load center homeline gantry lovely craneSquare d qo 30 amp load center wiring diagram. Check Details 30a load center wiring diagram Wiring diagram center load circuit breaker fault groundSquare d qo 30 amp load center wiring diagram Load center wiring homeline diagram square electrical main lug embellishment ge famous plug space amp circuit indoor menardsHomeline 70 amp load center wiring diagram gallery.ģ0 amp qo breaker wiring diagramBreakers 70a homeline fuse Homeline load center wiring diagram 70aHomeline load center wiring diagram 70a. Load center wiring diagram gallery Wiring diagram homeline amp load center Ge doityourself Ge powermark gold load center wiring diagram Diagrams gfci circuit prong receptacle dsl vac 240v centurylink starter starters basics dimmer dryer schematic homeline outlets types individual subpanels Breaker qo lug panels circuitos Ge powermark gold load center wiring diagram Square D Load Center Wiring Diagram - Wiring Diagram ![]() You can customize what permissions are granted to the cloned app, overriding what is actually allowed for the app. Sensitive device details like IMEI, IMSI, phone number, WiFi MAC address, Android ID can all be hidden from the cloned app. The clone app can be made to report fake GPS locations by specifying custom latitude and longitude coordinates. App Cloner can bypass these restrictions. Some apps try to restrict cloning and modding by detecting if an app is debuggable or identifies as a clone. This prevents cloned apps from knowing they are running on the same device. You can randomize or spoof the following app identifiers used for tracking and analytics: These powerful options allow modifying how cloned apps identify themselves and interact with the Android system. While basic cloning covers most people’s needs, App Cloner offers many advanced modding features through paid add-ons. Since clones can have custom icons and names, you can quickly identify and launch them.įor even faster switching, App Cloner provides a floating button that lets you instantly toggle between an original app and its clones. You can easily switch between original apps and their clones by using the app launcher. So if you ever wished you could use two WhatsApp or Instagram accounts on the same phone, App Cloner makes it possible. Have multiple installations of an app configured differently.Test experimental app features or versions.Log in with multiple accounts on the same app.The main difference is that the clone works completely separately and has its own isolated data and cache folders. Once an app is successfully cloned, you can use the cloned copy just like you would use the original app. Save cloned APK files to install on other devices or share with friends.Use the “Update” option to refresh clones with newer versions of original apps.Manage notifications separately for each clone.Customize cloned app icons so you can easily distinguish between originals and clones.Avoid cloning system apps and apps that handle sensitive data like banking and finance apps.Apps that use device-specific identifiers generally don’t work properly when cloned. Here are some useful tips when cloning apps with App Cloner: The cloned app will now appear under the “Clones” tab and you can launch it.When ready, tap the Clone button at the bottom to create the cloned copy.Customize the clone to your liking by changing its name, icon, layout, permissions, etc.Find the app you want to clone and tap on it. ![]() Open App Cloner and select the “Apps” tab at the bottom.Install App Cloner from the Google Play Store.Lightweight app – Uses very little memory and CPU resources so it doesn’t slow down your device.Ĭloning apps with App Cloner is very easy and straightforward.Paid add-ons allow accessing more advanced features. Ad-free experience – No annoying ads in the free version.Update clones separately – You can update clones separately from original apps so they don’t get affected by automatic updates.Mod cloned apps – Advanced modding options allow changing app identifiers, hiding device details, spoofing locations, bypassing restrictions, and more.Customize clones – You can customize cloned app names, icons, badges, colors, layouts, permissions, and many other options.They have their own data folders, cache, preferences, etc. Fully independent clones – The cloned copies are completely separate apps that run independently from the originals.It can clone most social media apps, messaging apps, productivity apps, and more. Clone almost any app – App Cloner supports cloning thousands of apps, with new ones being added all the time.Here are some of the standout features that make App Cloner such a great app cloning tool: In this comprehensive review, we will cover everything you need to know about App Cloner, including its features, usage, tips and tricks, pricing, and more. ![]() With over 9 million downloads and a 4.5-star rating on the Google Play Store, App Cloner is one of the most popular and highly-rated app cloners available.
![]() But every fire is different, and this safe is certainly better than no safe at all. That’s half the endurance and a significant reduction in temperature protection compared with our top pick, so choosing this safe means you’re at greater risk of losing the contents if disaster strikes. It’s large enough to hold 8.5-by-11-inch sheets of paper without the edges curling, and it’s rated to withstand a 1,550 ☏ fire for 30 minutes. ![]() Larry McKenna, a fire protection engineer at the US Fire Administration, told us you should “get the best you can afford.” The Union Safe Company Waterproof And Fire Rated Document Safe, sold exclusively at Harbor Freight, is the best option if you can’t spend $100 on a safe or if you have limited floor space. Measurements: 20 by 17.2 by 7.3 inches (WDH) Weight: 42 pounds Intertek ETL fireproof rating: one hour at 1,700 ☏ But we think the price and size are worth tolerating because this safe gives your stuff a greater chance of surviving a disaster. The additional protection makes the 1114 noticeably larger and heavier than other safes of similar capacities-it weighs 42 pounds and takes up the same amount of floor space as a mini fridge. It’s large enough to hold both letter- and legal-size sheets of paper without your having to fold them. Honeywell also says the safe will keep spray and flood water out for 100 hours. It’ll be cooler down near the floor, where you keep your safe. A house fire can peak at about 2,000 ☏, but this kind of heat occurs at the highest points in your home, namely the attic or at least the ceiling. The Honeywell 1114 Lightweight Fire and Waterproof Chest is independently verified by the safety organization Intertek to keep personal items safe during a fire for up to an hour-twice as long as the competition-in conditions as hot as 1,700 ☏. ![]() Formulated with a combination of sheer zinc oxide and titanium dioxide with prebiotics and soothing vitamin E to help protect skin from surface free radicals.100% mineral active sunscreen that reflects UVA/UVB rays to protect skin and prevent sunburn."bod圜ontent" : "Free radicals are unstable molecules that in small amounts are not necessarily harmful, but can cause damage to our bodies if we are overexposed to them.A lightweight, 100% mineral sunscreen for sensitive skin, designed for daily use on the face and body, reflects the sun’s damaging UVA/UVB rays and prevents sunburn. So, if you're concerned about uneven skin tone, it's important to protect yourself with sunscreen." ![]() But did you know that ultraviolet (UV) rays can also cause uneven skin tone? When the sun's UV rays penetrate the skin, they can trigger the production of melanin, resulting in dark spots or patches.UV rays can also cause inflammation and damage to skin cells, which can lead to premature aging and a loss of elasticity. "bod圜ontent" : "We all know that too much sun can be bad for our skin. "type_id" : "commerce_layouts.accordionPanel", "type_id" : "commerce_layouts.accordion", All of these factors can contribute to an uneven complexion.Let's take a closer look at these causes below.", This can lead to wrinkles, fine lines, and a loss of elasticity. As we age, our skin cells regenerate more slowly and our collagen production decreases. "richText" : "Finally, aging can also cause uneven skin tone. ![]() "path" : "/Articles/UnevenSkin/uneven-skincare-tips.jpg", Acne can cause both hyperpigmentation and scarring, which can lead to an uneven complexion.", Too much melanin causes hyperpigmentation, and hypopigmentation is where you have too little melanin.Hypopigmentation is often caused by injuries to the skin, genetic conditions, or diseases such as vitiligo.Hyperpigmentation has many causes including sun damage, inflammation, certain medications, and acne. One of the main causes of uneven skin tone is pigmentation disorders, where your skin produces too much or not enough melanin. "richText" : "Your skin gets its color from a pigment called melanin. "richText" : "What causes uneven skin tone? ", Texture refers to the feel of your skin-for example, if your skin feels rough and bumpy-while tone refers to the color of your skin.Understanding the difference between texture and tone may help you choose the right products for your skin type and achieve the best results.", "richText" : "Texture and tone are two important aspects of skin care. "richText" : "What is Uneven Skin Tone?", "imageQualityDropdown" : "2 Row x 1 Col (Mobile), 1 Row x 2 Col (Desktop)" "alt" : "uneven skin concerns and tips to treat", Fortunately, there are ways to manage uneven skin.", It can be caused by a variety of factors, such as sun exposure, aging, and genetics. "richText" : "Uneven skin tone is a common skin care concern. "richText" : "What is Uneven Skin Tone and How Can You Manage It?", "type_id" : "commerce_assets.editorialRichText", "type_id" : "commerce_layouts.mobileGrid2r1c", "type_id" : "commerce_layouts.mobileGrid1r1c", "articleDesc" : "Are you struggling with dull, uneven skin tone? Learn about what uneven skin tone is and its causes and discover tips to get your skin looking its best.", "articleTitle" : "What Is Uneven Skin Tone?", ![]() "articleImageAlt" : "What is Uneven Skin and How to Manage Your Skin", "alt" : "What is Uneven Skin and How to Manage Your Skin", "path" : "/Articles/UnevenSkin/how-to-manage-uneven-skin-hero.jpg", ![]() But remember, only professionals are trained to interpret polygraph and lie detector results using several more data points. You may have caught a spy! Real concepts and imaginative play You’ll learn real concepts of detecting truth and lies just like law enforcement and intelligence officers use. Do they start sweating when you ask questions? Very suspicious. ![]() ![]() Moisture sensing machine The fingertip sensor detects moisture. Hook them up to the machine and go through the liar detector cards to see how they react to each question. Please call customer service for returns.Details: Can you handle the truth? The Discovery Kids Electronic Lie Detector Portable Spy Kit teaches you tips and tricks for spotting when someone’s trying to hide the truth.If there's an issue, bring the item in store for help with your return. Return requires a hazmat label and special packaging. See our Extended Holiday Return Policy to see if this item qualifies. Enjoy a longer window to return most of your holiday purchases.Cannot ship to Northern Mariana, Marshall Islands, Armed Forces Europe, Federated States of Micronesia, Hawaii, Alaska, Armed Forces Pacific, Armed Forces Americas, Puerto Rico, American Samoa, Guam, Palau, U.S.This product will be delivered by Standard Ground Shipping and is not eligible for Premium or Overnight shipping.This item may not be shipped to Northern Mariana, Armed Forces Europe, Federated States of Micronesia, Hawaii, Alaska, Armed Forces Pacific, Armed Forces Americas, Puerto Rico, American Samoa, Guam, Palau, U.S.This item may not be shipped to Armed Forces Americas, Hawaii, American Samoa, Palau, Federated States of Micronesia, Puerto Rico, Armed Forces Europe, District of Columbia, Northern Mariana, Guam, Alaska, Marshall Islands, Armed Forces Pacific, U.S.Plastic - Silicone, Acrylonitrile Butadiene Styrene, Polyvinyl Chloride, Polyethylene Terephthalate, Iron.The starter smartphone comes with 20 songs preprogrammed as well as sounds effects, lights and other activities to keep your child's mind engaged and stimulated.Rechargeable- the discovery kids starter smartphone features a built-in rechargeable battery that charges via the included micro universal serial bus cable.Quiz mode- to complete the learning, kids can learn about colors, numbers, and animals through fun and engaging quizzes.Fidget popper- the removable case features a wrist lanyard and sensory fidget popper to help stimulate young children's minds as they develop fine motor skills.Play and learn- the discovery kids starter smartphone allows kids to play music and ringtones while enabling them to learn about colors, numbers, and more.Set includes - 1 toy cellphone, 1 toy phone case and 1 micro USB charging cable.Product dimensions - 7" L x 2.07" W x 9.5" H.Watch as they learn about colors, numbers, animals, and more in a modern way the smartphone is protected by unique fidget popper case that is as entertaining as it is practical. ![]() This starter smartphone comes with built-in activities that are fun and engaging for young minds. Both common and rare genetic variants are believed to underlie the pathophysiology of the prevalent types of migraine, migraine with typical aura and migraine without aura. Hansenīackground: Migraine has complex polygenic origins with a heritability of estimated 40–70%. Hansen 1,2 1Copehagen University Hospital, Danish Headache Center, Glostrup, Denmark 2Copenhagen University, Novo Nordic Foundation Center for Protein Research, Copenhagen, Denmark Correspondence: T. ![]() This supports that AF-mediated cardioembolism plays a significant role in the MwA-stroke association.Ī. The difference of AF probability between MwA and MwoA was significant in men, but not in women.Ĭonclusions: The probability of AF predicted by an AI-enabled ECG algorithm is significantly higher in patients with MwA compared to MwoA. After adjusting for age and sex, MwA patients had a higher mean probability of AF compared to MwoA (7.6%☐.5% vs. The MwA group was significantly older than MwoA (50.2 vs. Results: The analysis included 676 MwA and 1124 MwoA patients. The AI-ECG data with the highest predicted AF probability was used to compare the MwA and MwoA groups. Patients with AF and inconsistent diagnoses of migraine types were excluded. Methods: Adult patients with a MwA or MwoA diagnosis and at least one NSR ECG within the past 5 years at Mayo Clinic were identified. We aim to assess the probability of AF predicted by the AI-ECG algorithm in patients with MwA and MwoA. The Mayo Clinic Cardiology team developed an artificial intelligence-enabled ECG (AI-ECG) algorithm that predicts probability of AF in ECGs interpreted as normal sinus rhythm (NSR). Higher incidence of atrial fibrillation (AF) has been demonstrated in MwA compared to Migraine without aura (MwoA) in longitudinal cohort studies. Objective: Migraine with aura (MwA) is associated with a 2-fold risk of ischemic stroke. Chiang 6 1Mayo Clinic, Neurology, Scottsdale, AZ, United States 2Mayo Clinic, Cardiology, Scottsdale, AZ, United States 3Mayo Clinic, Quantitative Health Research, Scottsdale, AZ, United States 4Mayo Clinic, Neurology, Mankato, MN, United States 5Mayo Clinic, Cardiology, Rochester, MN, United States 6Mayo Clinic, Neurology, Rochester, MN, United States Correspondence: N. This data may help providers to use more rational polypharmacy. ![]() Whereas, the reported interaction is actually less, 60%, per FAERS. Per DrugBank, the chance of an interaction is >99% once more than 3 drugs are used in combination. 3 preventives was not analyzed.Ĭonclusion: The likelihood of an interaction increases as the number of combinations of abortives and preventives increases. ![]() Due to hardware limitations, 3 abortives vs. Table 1 contains the number of interactions for a given number of medications. We downloaded DrugBank data on Augand included FAERS data from October 2012 to March 2020. ![]() Results: We included 38 abortives and 23 preventives. If at least one interaction, of any type, is listed, then it is included here and compared across the two databases. All combinations of up to 3 abortives and/or preventives are screened for interactions through DrugBank and FAERS. Methods: We included, as input, abortive and preventive drugs from the AHS Position Statement on Integrating New Migraine Treatments into Clinical Practice, as well as Szperka"s, Migraine Care in the Era of COVID-19. Zhangīackground: This project aims to compare the likelihood of a theoretical drug-drug interaction between a number of abortives and preventives using DrugBank"s application programing interface (API) versus the empirically reported interactions using the FDA"s Adverse Event Reporting System (FAERS) API. Zhang Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, United States Correspondence: V. |
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